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Off-label use for hyperbilirubinemia: Phenobarbital induces glucuronyl transferase and hepatic bilirubin-binding Y-protein to reduced serum bilirubin concentrationsMonitor Carefully (one)phenobarbital will lower the extent or result of tofacitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Loss of, or lowered r

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Watch Intently (one)phenobarbital will reduce the extent or influence of fentanyl transmucosal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with CYP3A4 inducers may lead to a lessen in fentanyl plasma concentrations, not enough efficacy or, possibly, progress of the withdrawa

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